Propiverine hydrochloride

Research use only, not for human use.

Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).

Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).(In Vitro):Propiverine (10-3000 nM) inhibits the speci?c binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively.(In Vivo):Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo.

Propiverine (10-3000 nM) inhibits the speci?c binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively.

Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats.Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo. Animal Model:Female adult Sprague-Dawley rats (250-270 g)Dosage:5 mg dissolved in distilled water (0.5 mL)Administration: P.o. once daily for 2 weeks Result:Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly.Increased plasma epinephrine and norepinephrine levels.No significant changes were observed in body weight.

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Others

Other Targets

Others

Neurological Disease

Overactive bladder; Urinary incontinence

54556-98-8

403.94

C23H30ClNO3

>98% (HPLC)

DMSO:198 mM

Cl.CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years